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Tag Archives: Opana
FedEx Corp. is facing charges that it delivered prescription painkillers and other controlled substances for illegal Internet pharmacies.
The charges include 15 counts of conspiracy to distribute controlled substances and misbranded drugs and drug trafficking. Prosecutors claim FedEx delivered drugs to Internet pharmacies that supplied pills to customers who filled out online questionnaires without undergoing doctors’ examinations, in violation of federal and state drug laws.
According to the indictment, FedEx knew as early as 2004 that it was delivering drugs to dealers and addicts:
FedEx’s couriers in Kentucky, Tennessee, and Virginia expressed safety concerns that were circulated to FedEx Senior management, including that FedEx trucks were stopped on the road by online pharmacy customers demanding packages of pills, that the delivery address was a parking lot, school, or vacant home where several car loads of people were waiting for the FedEx driver to arrive with their drugs, that customers were jumping on the FedEx trucks and demanding online pharmacy packages, and that FedEx drivers were threatened if they insisted on delivering packages to the addresses instead of giving the packages to customers who demanded them. In response to these concerns, FedEx adopted a procedure whereby Internet pharmacy packages from problematic shippers were held for pick up at specific stations, rather than delivered to the recipient’s address.
Two California counties have launched a lawsuit accusing five major pharmaceutical companies of obscuring the addictive effects of OxyContin, Percocet and other powerful opioid painkillers while reaping billions of dollars in profits from the drugs. The companies deceived tens of millions of doctors and patients about the “significant dangers and questionable benefits of prescription opioids” for the treatment of long-term non-cancer pain, according to a complaint filed today in California state court. The five opioid manufacturers — Purdue Pharma, Cephalon, Janssen Pharmaceuticals, Endo Health Solutions, and Actavis — concealed the dangerously addictive nature of the medicines while touting benefits that had no scientific support, in order to expand the market for the drugs and boost profits, the lawsuit alleges.
The complaint charges that the pharmaceutical companies marketed opioids as “rarely” addictive, misrepresented the evidence of their efficacy for treating chronic non-cancer pain, trivialized their serious side effects and falsely assured doctors and consumers that opioids were safer than over-the-counter drugs.
According to the suit:
These pharmaceutical companies have a long history of aggressively marketing these dangerous drugs through sophisticated campaigns. These campaigns employ industry-funded professional associations, patient advocacy groups, and physicians to deceive consumers and their doctors about the harms and purported benefits of opioids for treating chronic pain.
There are many reasons why teenagers get hooked on prescription drugs, but new research conducted at the University of Michigan has found that those who are prescribed pain relievers are at “notable risk” for abusing opioid drugs.
A University of Michigan researcher found that teens may develop an increased tolerance to the medication, which can lead to continued use of the drug after the initial prescription is finished.
According to the researcher:
“Once an adolescent has been medically exposed to a potentially addictive medication, adolescents are more likely to engage in nonmedical use and diversion, including buying, selling and giving away pills.”
Earlier this year, a separate study found that one in four teens has misused or abused a prescription drug at least once in their lifetime – a 33% increase over the past five years – up from 18% in 2008.
Of those kids who said they abused prescription medications, one in five (20%) had done so before age 14, that survey found.
Easy access to powerful prescription opiates has led to a rise in overdose deaths among war veterans, a new report has found. According to the Center for Investigative Reporting, the Department of Veterans Affairs has issued more than one opiate prescription per patient, on average, for the past two years. Prescriptions for four opiates – hydrocodone, oxycodone, methadone and morphine – have surged by 270% in the past 12 years, CIR found in an analysis of data obtained through a Freedom of Information Act request.
According to CIR:
The agency charged with helping veterans recover from war instead masks their pain with potent drugs, feeding addictions and contributing to a fatal overdose rate among VA patients that is nearly double the national average.
CIR notes that this spike in opiate prescriptions has occurred despite new VA regulations laid out in 2009 requiring clinicians to follow an “integrated approach” to helping veterans in pain, including a stronger focus on treating the root causes of pain rather than using powerful narcotics to reduce symptoms.
Many areas of the nation with military bases and large VA hospitals have seen prescription drug abuse skyrocket among American soldiers in recent years.
Today is International Overdose Awareness Day. Drug overdose death rates worldwide are skyrocketing: of the estimated 78,000 deaths in 2010 because of illegal drug use, more than half were due to painkillers, according to a recent study published in the medical journal The Lancet. And in the U.S., drug overdose is now the number one cause of accidental death of Americans between the ages of 35 and 54, killing over 38,000 people in 2010; many of these deaths were caused by prescription opiates.
The painkiller addiction epidemic has also led to a rise in heroin abuse. A new report by the Substance Abuse and Mental Health Services Administration also found that found that four out of five recent heroin initiates — about 79% — previously used prescription pain relievers non-medically. According to SAMHSA, the number of people reporting that they have used heroin in the past 12 months rose from 373,000 people in 2007 to 620,000 people in 2011. Similarly, the number of people dependent on heroin in the past 12 months climbed from 179,000 people in 2007 to 369,000 people in 2011.
Overdose deaths due to prescription painkillers have been on the rise among all segments of the population, but a new analysis of federal data by the U.S. Centers for Disease Control and Prevention has found that such deaths have quintupled among women since 1999.
Although more men are still dying of prescription drug overdoses, women are catching up: in the last 14 years, the percentage increase in deaths has been greater for women, spiking by 400% as opposed to 265% for men, the CDC says.
According to the agency, 6,631 women died of opioid overdoses in 2010 — more than twice the number who die from cervical cancer — compared with 10,020 men; in addition, while younger women in their 20s and 30s tend to have the highest rates of opioid abuse, the overdose death rate was highest among women ages 45 to 54.
In 2010, there were more than 200,000 emergency room department visits for misuse of opioids among women, one every three minutes, the CDC says.
The U.S. Food and Drug Administration said Friday it will continue to allow sales of the generic version of the painkiller Opana that does not include an abuse-resistant feature.
Opana’s manufacturer, Endo Pharmaceuticals, had submitted a petition to the agency asking it to ban generic forms of the painkiller, which Endo has reformulated as “Opana ER” to make it harder to abuse. That petition was denied by the FDA, which said Endo’s reformulation was not significantly safer than the original version:
While there is an increased ability of the reformulated version of Opana ER to resist crushing relative to the original formulation, study data show that the reformulated version’s extended-release features can be compromised when subjected to other forms of manipulation, such as cutting, grinding, or chewing, followed by swallowing. Reformulated Opana ER can be readily prepared for injection, despite Endo’s claim that these tablets have “resistance to aqueous extraction (i.e., poor syringeability).” It also appears that reformulated Opana ER can be prepared for snorting using commonly available tools and methods.
Endo’s petition came after Purdue Pharma successfully asked the FDA to ban any generic versions of OxyContin based on the powerful painkiller’s original formulation, which does not include anti-abuse features designed to make it more difficult to crush, break, or dissolve.
Prescription painkiller sales are set to increase by 15% and hit $8.4 billion by 2017, due in part to the U.S. Food and Drug Administration’s recent decision to ban any generic versions of OxyContin based on the powerful painkiller’s original formulation, which does not include anti-abuse features designed to make the pill harder to abuse. Experts are predicting a race across the pharmaceutical industry to create a market where all opioids have abuse-deterrent properties, according to the Wall Street Journal.
According to the FDA, “because original OxyContin provides the same therapeutic benefits as reformulated OxyContin, but poses an increased potential for certain types of abuse, the FDA has determined that the benefits of original OxyContin no longer outweigh its risks and that original OxyContin was withdrawn from sale for reasons of safety or effectiveness.”
OxyContin’s manufacturer, Purdue Pharma, reformulated the drug in 2010 to make it more difficult to crush, break, or dissolve; the reformulated pill forms a viscous hydrogel and cannot be easily prepared for injection. The FDA noted Tuesday that abuse of OxyContin by these routes, as well as the oral route, is still possible.
The rate of reported drug overdoses in the U.S. more than doubled between 1999 and 2010, with about half of the additional deaths falling under the pharmaceuticals category, according to this article in Popular Science. The data, which was compiled from WONDER, the CDC National Center for Health Statistics’ multiple cause of death database, showed that nearly three-quarters of the pharmaceuticals deaths were due to opioid analgesics such as OxyContin and Vicodin.
The CDC recently found that drug overdose deaths increased for the eleventh consecutive year in 2010. According to the agency, 38,329 people died from a drug overdose in the U.S. that year, up from 37,004 deaths in 2009.
Overdose deaths involving opioid analgesics have shown a similar increase, the CDC found: starting with 4,030 deaths in 1999, the number of deaths increased to 15,597 in 2009 and 16,651 in 2010.
In 2010, nearly 60% of the drug overdose deaths (22,134) involved pharmaceutical drugs. Opioid analgesics, such as oxycodone, hydrocodone, and methadone, were involved in about 3 of every 4 pharmaceutical overdose deaths (16,651), according to the CDC.
One in four teens has misused or abused a prescription drug at least once in their lifetime – a 33% increase over the past five years – up from 18% in 2008, according to a new survey, The Partnership Attitude Tracking Study (PATS), by the Partnership at Drugfree.org and MetLife Foundation. That translates to about 5 million teens.
In addition, one in eight teens reported that at least once in their lifetime, they had taken the stimulants Ritalin or Adderall when those medications weren’t prescribed for them, the survey found.
Even more disturbing was the fact that almost one in four teens (23%) said their parents didn’t care as much if they were caught using prescription drugs without a doctor’s prescription, as compared to getting caught with illegal drugs. And more than a quarter of teens (27%) mistakenly believed that misusing and abusing prescription drugs was safer than using street drugs, with 33% saying they believed it was “okay to use prescription drugs that were not prescribed to them to deal with an injury, illness or physical pain.”
Of those kids who said they abused prescription medications, one in five (20%) had done so before age 14, the survey found.