Tag Archives: hydrocodone

Judge nixes Zohydro ban in Mass.

gavelA federal judge has struck down Massachusetts Gov. Deval Patrick’s ban on the controversial new form of hydrocodone, Zohydro, saying the state lacked the authority to override the FDA’s approval of the painkiller. U.S. District Court Judge Rya W. Zobel noted that the FDA approved Zohydro after a screening process, and said the federal regulatory agency has more power than the state in this case, according to this article. She also said Massachusetts lacked the authority to force Zohydro’s maker, Zogenix, to make an abuse-resistant form of the drug because that formulation has not been approved by the FDA, the article says.

Gov. Patrick issued the Zohydro ban last month, declaring a public health emergency in response to the state’s growing opioid addiction epidemic and taking a number of other steps to curb overdoses and help the addicted. In a press release, the governor said the use of oxycodone and other narcotic painkillers, often as a route to heroin addiction, has been on the rise for the last few years in Massachusetts; at least 140 people have died from suspected heroin overdoses in communities across the state in the last several months, levels previously unseen. From 2000 to 2012, the number of unintentional opiate overdoses increased by 90 percent, he added.

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Mass. Gov. bans Zohydro amid opioid epidemic

pills and pill bottlesMassachusetts Governor Deval Patrick has declared a public health emergency in response to the state’s growing opioid addiction epidemic, issuing an order banning the controversial new form of hydrocodone, Zohydro, and taking a number of other steps to curb overdoses and help the addicted. In a press release, the governor said the use of oxycodone and other narcotic painkillers, often as a route to heroin addiction, has been on the rise for the last few years in Massachusetts; at least 140 people have died from suspected heroin overdoses in communities across the state in the last several months, levels previously unseen. From 2000 to 2012, the number of unintentional opiate overdoses increased by 90 percent, he added. The prescribing and dispensing of Zohydro, which was recently approved for sale by the FDA despite widespread protests, will be prohibited “until it is determined that adequate measures are in place to safeguard against the potential for diversion, overdose and misuse,” he said. The governor added:

The introduction of this new painkiller into the market poses a significant risk to individuals already addicted to opiates and to the public at large.

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ERs prescribing more painkillers: study

RXIncreasing numbers of Americans are being prescribed powerful opiate painkillers during emergency room visits, a new study has found. Between 2001 and 2010, emergency departments in the United States showed a 49 percent increase in prescriptions for narcotic painkillers despite the fact that there was only a small increase in the percentage of visits for painful conditions.

The study, published in the journal Academic Emergency Medicine, found that in 2010, 31 percent of ER visits involved a narcotic painkiller prescription, up from about 21 percent in 2001.

These increases were seen for conditions including abdominal pain, back pain, headache, joint and muscle pain, and toothaches.

In addition, the study found that hydromorphone and oxycodone had the greatest increase in ER administration between 2005 and 2010, while oxycodone and hydrocodone had the greatest increases in discharge prescriptions.

About 12 million Americans abused prescription painkillers in 2010, while roughly 15,000 Americans die annually from overdosing on such drugs, according to the U.S. Centers for Disease Control and Prevention.

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Zohydro critics fear new wave of addiction

Vicodin-half-life-how-long-does-Vicodin-remain-in-your-body2The U.S. Food and Drug Administration’s approval of Zogenix Inc.’s Zohydro painkiller has come under fire from critics who say the agency should not be approving any additional opioids given the current prescription drug epidemic. Forty-two public health groups are urging the FDA to withdraw its support of the painkiller, according to National Public Radio. Zogenix says it will introduce a non-crushable version of Zohydro in three years and plans to closely monitor prescription abuse, and claims that millions legitimately need the drug, NPR reports. But addiction experts say another high-potent, high-dose, long-acting opioid drug will simply add more fuel to the painkiller addiction epidemic, NPR says.

The green light for Zohydro, a new version of pure, extended-release hydrocodone that is said to be 10 times more powerful than Vicodin, came after an FDA advisory panel last year voted against approving the drug, citing concerns about the danger of addiction posed by the opioid drug class.

Unlike other hydrocodone-containing drugs like Vicodin, Lortab and Norco, Zohydro is not buffered with acetaminophen or some other over-the-counter medication. The drug also lacks an abuse-deterrent feature such as the ones used in new formulations of drugs like OxyContin.

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Pain pill prescriptions fueling teen addiction: study

teendrugsThere are many reasons why teenagers get hooked on prescription drugs, but new research conducted at the University of Michigan has found that those who are prescribed pain relievers are at “notable risk” for abusing opioid drugs.

A University of Michigan researcher found that teens may develop an increased tolerance to the medication, which can lead to continued use of the drug after the initial prescription is finished.

According to the researcher:

“Once an adolescent has been medically exposed to a potentially addictive medication, adolescents are more likely to engage in nonmedical use and diversion, including buying, selling and giving away pills.”

Earlier this year, a separate study found that one in four teens has misused or abused a prescription drug at least once in their lifetime – a 33% increase over the past five years – up from 18% in 2008.

Of those kids who said they abused prescription medications, one in five (20%) had done so before age 14, that survey found.

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Heroin abuse parallels rise in prescription drug addiction

heroinfoilWhile the abuse of painkillers has become a focus for concern, the corresponding rise in heroin use is also prompting calls for action, according to National Public Radio. In several states, including Wisconsin, legislation has been introduced to give people legal protection when calling 911 about an overdose, NPR says.

The number of people reporting heroin use in the previous year increased between 2007 and 2012, from 373,000 to 669,000, while nearly 80 percent of people who had used heroin in 2011 had also previously abused prescription painkillers classified as opioids, according to NPR.

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FDA OKs controversial form of Vicodin

pills and pill bottlesThe U.S. Food and Drug Administration has approved Zogenix Inc.’s Zohydro painkiller, a new version of pure, extended-release hydrocodone that is said to be 10 times more powerful than Vicodin. The move comes amid criticism from those who say the FDA should not be approving any additional opioids given the current prescription drug addiction epidemic. An advisory panel last year voted against approving Zohydro, citing concerns about the danger of addiction posed by the opioid drug class.

Unlike other hydrocodone-containing drugs like Vicodin, Lortab and Norco, Zohydro is not buffered with acetaminophen or some other over-the-counter medication. The drug also lacks an abuse-deterrent feature such as the ones used in new formulations of drugs like OxyContin.

Hydrocodone is currently the second most-abused medicine in the U.S. behind oxycodone.

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FDA moves for stricter hydrocodone controls

bunchofpillsThe U.S. Food and Drug Administration has recommended reclassifying hydrocodone-containing painkillers like Vicodin from Schedule III drugs to the more restrictive Schedule II, a move that would bring such medications in line with opioid painkillers such as oxycodone and morphine.

In January, an expert panel advising the FDA voted 19 to 10 in favor of the more stringent prescribing requirements. Proponents of the reclassification have noted hydrocodone’s abuse potential (such products are currently the most-abused prescription medicine behind oxycodone), while critics have argued that the move would hinder legitimate pain patients from obtaining treatment.

The reclassification must be approved by the Department of Health and Human Services and the Drug Enforcement Administration, which will make a final scheduling decision.

Separately in September, the FDA announced new safety labeling changes for extended-release and long-acting opioid analgesics such as OxyContin. The updated labels must state that such medications are indicated for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment.

In addition, because of the risk of addiction and abuse “even at recommended doses,” as well as the greater risks of overdose and death, the drugs must be labeled as “reserved for use in patients for whom alternative treatment options (e.g., non-opioid analgesics or immediate-release opioids) are ineffective, not tolerated, or would be otherwise inadequate to provide sufficient management of pain,” the agency said.

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Drug-dependent newborn rate on the rise in Tenn.

babybottleDriven by the prescription drug addiction epidemic, Tennessee is seeing a dramatic rise in the number of newborns born dependent on drugs. In just slightly more than nine months this year, more babies in the state have been born dependent on drugs their mothers took during pregnancy than in all of 2011, according to this article. By the first week of October, 643 babies were born dependent, compared with 629 for all of 2011, and officials are projecting more than 800 drug dependent babies by the end of this year, the article says. The majority of these births involved a mother taking medicine prescribed by a health care provider, according to the article.

Newborns being born addicted to painkillers is yet another disturbing trend stemming from the rampant abuse of prescription drugs. Nationwide, the number of pregnant women who were dependent on or using opiates when they delivered increased from 4,839 in 2000 to 23,009 in 2009.

As a result, the incidence of babies being born with neonatal abstinence syndrome, a group of problems caused by maternal opiate use during pregnancy, has nearly tripled in the past decade. In 2009, the syndrome was diagnosed in newborns at a rate of 3.4 per 1,000 hospital births per year, up from 1.2 diagnoses per 1,000 births per year in 2000.

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VA over-prescribing narcotics to vets: report

soldier drugsEasy access to powerful prescription opiates has led to a rise in overdose deaths among war veterans, a new report has found. According to the Center for Investigative Reporting, the Department of Veterans Affairs has issued more than one opiate prescription per patient, on average, for the past two years. Prescriptions for four opiates – hydrocodone, oxycodone, methadone and morphine – have surged by 270% in the past 12 years, CIR found in an analysis of data obtained through a Freedom of Information Act request.

According to CIR:

The agency charged with helping veterans recover from war instead masks their pain with potent drugs, feeding addictions and contributing to a fatal overdose rate among VA patients that is nearly double the national average.

CIR notes that this spike in opiate prescriptions has occurred despite new VA regulations laid out in 2009 requiring clinicians to follow an “integrated approach” to helping veterans in pain, including a stronger focus on treating the root causes of pain rather than using powerful narcotics to reduce symptoms.

Many areas of the nation with military bases and large VA hospitals have seen prescription drug abuse skyrocket among American soldiers in recent years.

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